Lung cancer is the growth of cancer cells that are not controlled in the lung tissue. Pathogenesis of lung cancer is not completely understood. Looks like bronchial mucosal cells metaplastik changes in response to chronic exposure to inhaled particles and injured lung. In response to cellular injury, inflammatory reactions and processes will evolve. Basal cell will undergo mucosal proliferation and differentiated into mucus-secreting goblet cells. It looks like the turn of events caused metaplastik layer columnar epithelium with squamous epithelium, which is accompanied by cellular atipia and increased mitotic activity which developed into mucosal dysplasia. The range of time this process has not been established, only estimated to be between 10 to 20 years.
The origin of the causes of lung cancer cells is still unclear. During these two theories evolve,
- • Theory pleuripotential cell by Auerbach, who explains the deviations that occur in the process of differentiation of stem cells into other cells.
- • Theory of a small cell by Yesner, which explains the small cell neoplasms transforming and evolving into cancer cells
However, it is known that genetic mutations in p73, p53 and PRB, in addition to the role of c-MYB oncogene, c-MYCA, mycc c-, c-raf, L-myc, N-myc, K-taste, c-Fura, N-race, H-ra, c-erbB1, c-fms, c-fes, c-RLF, c-erbB1, c-ErbB2, c-sis, BCL1.
According to WHO, lung cancer is the leading cause of death in the group of cancer in both men and women
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